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This section includes RHL summaries of published systematic reviews on HIV/AIDS. This includes information on the prevention of HIV through clinical, behavioral and social interventions. It also includes RHL summaries on the management of HIV, including the use of antiretroviral drugs and adjuvant therapies, promoting treatment adherence, and managing HIV/AIDS-related complications.

Management of HIV/AIDS

Micronutrient supplementation in children and adults with HIV infection

Further research is needed on the benefits of both multiple micronutrient and vitamin A supplementation.

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Micronutrient supplementation in pregnant women with HIV infection

The available evidence is inadequate to determine the effect of micronutrient supplementation in pregnant women living with HIV who are being treated with antiretroviral medications.

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Integration of sexually transmitted infection (STI) services into HIV care and treatment services for women living with HIV

The review found evidence for the feasibility and potential of positive outcomes of integrating STI and HIV care. For women living with HIV, there was an increase in Pap smear coverage in the fully integrated clinic, but there was no significant difference found in rates of sexual health services...

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Motivational interviewing for improving outcomes in youth living with HIV

Motivational interviewing may help youth living with HIV to reduce short-term viral loads, unprotected intercourse and alcohol use.

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Interventions to address unequal gender and power relations and improve self-efficacy and empowerment for sexual and reproductive health decision-making for women living with HIV

Empowerment interventions might help support the sexual and reproductive health (SRH) and rights of women living with HIV, particularly by preventing STIs.

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Integration of family planning services into HIV care and treatment services

Integration of family planning into HIV care was associated with higher modern method contraceptive use and knowledge across the different settings and models of integration. Even though use of FP increased, levels were still low.

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HIV prevention

Behavioural interventions to promote condom use among women living with HIV

In this review, behavioral interventions to promote condom use and/or modify risky sexual behaviours among women living with HIV failed to demonstrate any positive effects on behaviour change in favour of consistent condom use during intercourse.

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Male circumcision for prevention of heterosexual acquisition of HIV in men

Male circumcision offers significant protection to men against the acquisition of HIV during heterosexual sex. The conclusions of this review would be applicable to all under-resourced settings, especially where circumcision is already practised and where the heterosexual HIV transmission is...

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Behavioural interventions to reduce the transmission of HIV infection among sex workers and their clients in low- and middle-income countries

Behavioural interventions appear to reduce the rates of transmission of sexually transmitted infections such as gonorrhoea, syphilis, genital warts, and chlamydial infections among sex workers in low- and middle-income countries. The interventions were also found to be effective in increasing...

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Social marketing interventions to increase HIV/STI testing uptake among men who have sex with men and male-to-female transgender women

Limited evidence from developed countries suggests that multi-media social marking interventions can significantly increase HIV testing uptake among men who have sex with men. In the absence of studies from under-resourced settings, it is unclear whether such interventions would also promote HIV...

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Population-based biomedical sexually transmitted infection control interventions for reducing HIV infection

This review did not find evidence to support the hypothesis that interventions to control sexually transmitted infections are an effective HIV prevention strategy at the population level. However, some of the interventions studied reduced the prevalence of syphilis and gonorrhoea at the population...

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WHO recommendation on pre-exposure prophylaxis for HIV prevention

Oral pre-exposure prophylaxis (PrEP) containing tenofovir disoproxil fumarate (TDF) should be offered as an additional prevention choice for pregnant women at substantial risk of HIV infection as part of combination prevention approaches.

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Interventions to prevent HIV/AIDS among adolescents in less developed countries: are they effective?

The studies generally showed only weak or modest improvements in knowledge about HIV and AIDS, altering attitudes, improving negotiation and communication skills or change in behaviour change (e.g. habitual use of condoms), abstinence, or decreasing the number of partners. Higher quality studies...

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