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Sexually transmitted infections

This section includes RHL summaries of published systematic reviews on the prevention and treatment of sexually transmitted and reproductive tract infections. For RHL summaries related to HIV/AIDS, please see the separate HIV topic page.

STI treatment

Interventions for trichomoniasis in pregnancy

Metronidazole is effective against trichomoniasis during pregnancy, but it may increase the risk of preterm birth. The intervention is clearly feasible in under-resourced settings as metronidazole is relatively inexpensive and available as a generic product.

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WHO guidelines for the treatment of Genital Herpes Simplex Virus

Since the publication of the World Health Organization (WHO) Guidelines for the management of sexually transmitted infections in 2003, changes in the epidemiology of STIs and advancements in prevention, diagnosis and treatment necessitate changes in STI management. These guidelines provide updated...

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Imiquimod for anogenital warts in non-immunocompromised adults

The available research comparing imiquimod to placebo or other treatments for the treatment of anogenital warts is of very low quality. Further research is required to guide practice in this area.

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Population-based biomedical sexually transmitted infection control interventions for reducing HIV infection

This review did not find evidence to support the hypothesis that interventions to control sexually transmitted infections are an effective HIV prevention strategy at the population level. However, some of the interventions studied reduced the prevalence of syphilis and gonorrhoea at the population...

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Trichomoniasis treatment in women

Short treatment regimens with drugs of the nitroimidazole class are as effective as the longer treatment regimens. Among varying nitroimidazole drugs available for the therapy of trichomoniasis, tinidazole was more effective than metronidazole. Identifying women infected with trichomoniasis is...

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Management of gonorrhoea and Chlamydia trachomatis infections in pregnancy

Antibiotics are effective in the treatment of gonorrhoea and chlamydia in pregnancy, but before accepting the results of this review and deciding on which treatment regimen to follow, it would be essential for each country to determine the prevalence of penicillinase-producing Neisseria gonorrhoea.

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STI prevention

Nonoxynol-9 for preventing vaginal acquisition of sexually transmitted infections by women from men

Nonoxynol-9 does not protect against sexually transmitted infections, and there is some evidence that it may cause harm by increasing the incidence of genital ulceration. As such, this product cannot be advised for STI prevention.

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Diagnosis and detection of STIs

Social marketing interventions to increase HIV/STI testing uptake among men who have sex with men and male-to-female transgender women

Limited evidence from developed countries suggests that multi-media social marking interventions can significantly increase HIV testing uptake among men who have sex with men. In the absence of studies from under-resourced settings, it is unclear whether such interventions would also promote HIV...

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