Stop Sepsis

Maternal sepsis is a major cause of maternal morbidity and mortality worldwide. At present, evidence on the best strategies and resources to prevent and manage maternal sepsis, particularly in resource-constrained settings, is lacking. However, there is currently no consensus on what the focus of maternal sepsis research priorities should be; a necessary step in ensuring research conducted is meaningful and productive. PROGRESS aims to identify priorities for global research into maternal sepsis and outline a research agenda for achievement by 2035, bringing together the knowledge and experience of both professional stakeholders and patient/community stakeholders in resource-constrained settings. Almost 1000 potential questions on maternal sepsis were submitted by patients, healthcare workers, researchers and policymakers from all global regions in stage 1 of PROGRESS, in September 2024. Further questions were identified from review of research gaps in international guidelines, systematic reviews and previous research prioritization exercises. These questions will be combined and prioritize by both professional stakeholders and patient/community stakeholders during online surveys (stage 2) and a final consensus meeting in 2025 (stage 3).