An International Collaboration to Implement and Evaluate at Scale the Active Prevention and Treatment of Maternal Sepsis (APT-Sepsis Programme)


The Active Prevention and Treatment of Maternal Sepsis (APT-Sepsis) is a carefully developed programme designed specifically to be used in countries and facilities where there are limited resources available. The programme will be implemented in a cluster randomised, hybrid implementation effectiveness trial in 60 health facilities in Malawi and Uganda.

It builds on WHO recommendations and research evidence on 3 domains:

  • ‘hand hygiene’, ensuring compliance with the WHO 5 moments of hand hygiene
  • infection prevention and management and ensures adoption of evidence-based practices for infection prevention in maternity, including appropriate antibiotic prophylaxis for high-risk women and improved surgical practices, following WHO guidance
  • improved maternal sepsis management, including regular vital sign monitoring and act rapidly to ensure women with suspected sepsis are given all the correct initial treatments using a specially developed maternal sepsis treatment “bundle” (the FAST-M maternal sepsis bundle)

Generating evidence on effective strategies to prevent and treat maternal sepsis

This project is supported by:

The Joint Global Health Scheme with funding from the UK Foreign, Commonwealth and Development Office, the UK Medical Research Council (MRC), The UK Department of Health and Social Care through the National Institute of Health Research (NIHR), Wellcome (Grant ref: MRV005782/1) and HRP.